how do DDR pathways coordinate DNA repair with the resumption of stalled replication forks on the template

... replication enzymes have also been informative (Liu and Lou, 2017; Mueller ... template-directed 5′-3′ polymerase (pol), 3′-5′ exonuclease (exo) and 5 ... Jan 22, 2025 ... They provide a redundant copy of genetic information in each DNA strand. They enable template-dependent processes such as DNA replication and ... 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress ... information on your browser, mostly in ... Our findings will not only illuminate the mechanistic principles of DSB repair pathway choice but will also provide actionable information to help guide the ... Only when this model was proposed did DNA's potential for replication and information encoding become apparent. ... template, or mold, for the synthesis of a new ... DNA polymerase, an enzyme, recognizes each base in a template strand and matches it to the complementary base in a free nucleotide. The enzyme then catalyzes ... example, DNA synthesis may be effectively inhibited by drugs targeting the ... information. Crystallographic Methods and Protocols, 173-203. Tiew, K.-C ... Mar 1, 2022 ... DNA carries all the information needed for DNA replication and transfer new information to new cells. ... form replication forks. Each ... Aug 31, 2020 ... ... information from DNA and use it to build proteins ... Similar to the way DNA is used as a template in DNA replication, it is again used as a ... May 14, 2016 ... In order to have all the information for transcription and translation on a single strand in a non-cryptic form, the individual genes would all ...