What are the genetic mechanisms that lead to ribosome-mediated antibiotic resistance?

Abstract. Ribosomes are highly conserved macromolecular machines responsible for protein synthesis in all living organisms. Work published in the past year ... Aug 5, 2009 ... ribosomes. At a later stage, these initial RNA genes underwent optimization to produce more defined, relatively stable pockets, and when the ... Ribosome biogenesis is a multistep process that starts in the nucleolus and culminates in the formation of functional ribosomes in the cell. As calculated in the fourth column of the table, and schematically in Figure 1, at a fast doubling time of 24 minutes the 72,000 ribosomes per cell represent ... Sep 19, 2023 ... Elinor Breiner Goldshtein is a researcher on Merck's life science R&D team, which develops proteins and enzymes for the global research market. Jun 3, 2008 ... Orthogonal ribosomes (o-ribosomes), also known as specialized ribosomes, are able to selectively trans- late mRNA not recognized by host ... Ribosomes make proteins in all living organisms. They do this by decoding the genetic information, translating the three-letter code of DNA into the single ... The ribosome that is synthesizing the protein is directly attached to the ER membrane. These membrane-bound ribosomes coat the surface of the ER, creating ... Apr 21, 2025 ... ribosome ... ribosome, particle that is present in large numbers in all living cells and serves as the site of protein synthesis. Ribosomes occur ... Sep 28, 2006 ... However, Sec61 has a high affinity for nontranslating ribosomes and it is largely occupied in vivo. We addressed how RNC-SRP complexes can ...