What are the causes and consequences of ribosome stalling?

For over 40 years, scientists have studied the machine that synthesizes proteins. Yet, until recently, no one had "seen" the ribosome with any great ... The first atomic-resolution map of a ribosome, a cell's protein factory, suggests that RNA catalyzes the formation of proteins. Sep 14, 2021 ... In a new study, scientists in the lab of Sebastian Klinge provide the most detailed view of how human small ribosomal subunits are put together. Apr 24, 2020 ... In this review, we discuss ribosome heterogeneity that arises from multiple features of rRNAs, including rRNA variants and rRNA modifications, and ribosomal ... May 9, 2024 ... New research solves the 50-year-old mystery regarding the fate of spent ribosomes and suggests a dynamic enzyme is vital for the “quality control” process. In this Perspective, we discuss ribosome heterogeneity, where ribosomes of distinct compositions may be present both within cells and across tissues. Mar 25, 2014 ... Most antibiotics attack bacteria by disabling their ribosomes, and the bacteria fight back with compensating mutations. Using X-rays ... May 8, 2013 ... ... ribosome and how it can be inhibited by drugs. His laboratory has established modes of action of several important classes of antibiotics ... Aug 8, 2023 ... Membrane-bound ribosomes in the RER translate the mature mRNA transcript into amino acids that are attached to become polypeptides. Eukaryotic ... Apr 29, 2024 ... ... they do. By investigating differences among ribosomes, we may be opening the door to drugs that target specific pathogenic bacteria […]