How do some antibiotics inhibit bacterial protein synthesis?

Ribosome biogenesis is a multistep process that starts in the nucleolus and culminates in the formation of functional ribosomes in the cell. Jan 25, 2017 ... How proteins fold continues to perplex researchers. Now, new tools show that the ribosome not only synthesizes proteins, it also helps them ... The first atomic-resolution map of a ribosome, a cell's protein factory, suggests that RNA catalyzes the formation of proteins. Five years ago, Yale scientists made a splash with the long-sought atomic structure of the large subunit of the ribosome, the protein-synthesizing factory ... Apr 22, 2021 ... RIBOSOME REARRANGED. To help reach his goals, Badran has developed what's known as an “orthogonal translation” system, in which a cell contains ... Jan 31, 2025 ... The researchers discovered that ribosomes help each other when encountering difficulties, a process they refer to as 'ribosome cooperativity'. Nov 10, 2015 ... ... of whole Escherichia coli treated with the antimicrobial peptide MSI-78 indicate a multi-hit mechanism with ribosomes as a novel target. High-resolution structures of prokaryotic and eukaryotic ribosomes, including the ribosomes from pathogenic organisms, in complex with antibiotics; Structure ... Life sciences/Cell biology/Cellular physiology/Cell morphology/Cell structure/Organelles/Ribosomes. Learn More About the 2022 Neimark Awardees. Prokaryotes have ribosomes that are slightly smaller than eukaryotes. Prokaryotic cells have ribosomes made of 50-S and 30-S subunits. Both subunits are ...