How can we improve the efficiency and fidelity of in vitro translation systems?

Congenital mutations in RPS19 and other genes encoding ribosomal proteins cause Diamond-Blackfan anemia, a disorder characterized by hypoplastic, macrocytic ... Apr 8, 2014 ... Mutations in some of the proteins that make ribosomes cause disorders characterized by bone marrow failure and anemia early in life, followed by ... The eukaryotic ribosome is much larger than it is in bacteria, and its activity is fundamentally different in many key ways. Jan 19, 2022 ... Aging impairs the ability of ribosomes to efficiently synthesize proteins and leads to protein misfolding and aggregation, which disrupts cellular health. In addition to their central functions in translation, ribosomes can adopt inactive structures that are fully assembled yet devoid of mRNA. Ribosomes make proteins in all living organisms. They do this by decoding the genetic information, translating the three-letter code of DNA into the single ... Jun 21, 2017 ... illustration of a ribosome translating proteins Ribosomes, which build a protein (black) from an RNA strand (blue), may specialize in making ... Mar 7, 2025 ... Ribosomes are not uniform—they have subtypes! This work challenges an age-old notion that Ribosomes are homogenous translators of RNA. Feb 26, 2024 ... Using electron microscopy, scientists have recently managed to produce a 3D model of a part of the human cell, the ribosome. Jun 3, 2008 ... Orthogonal ribosomes (o-ribosomes), also known as specialized ribosomes, are able to selectively trans- late mRNA not recognized by host ...