What are the potential strategies for mitigating the effects of aging on germ cell quality?

We generated a gene-edited chicken, in which germ cells can be ablated in a drug-dependent manner, as recipients for gene-edited PGC transfer. ... germ cell. Germ cells are the cells that make the eggs (ova) in females and the sperm in males. Germ cell tumors (GCTs) are made up of these underdeveloped ... Testicular cancers start in germ cells. These are cells in the testicles that make sperm. These tumors often start in the testicles. Yolk sac tumors are the most common malignant testicular and ovarian tumors in children. Most yolk sac tumors will require surgery and chemotherapy, regardless ... "Germ Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Germinomas. Germinomas are malignant germ cell tumors. Germinomas are also termed dysgerminoma when located in the ovaries; and seminoma when located in the ... Oct 1, 2021 ... Spermatocytic Tumors. A spermatocytic tumor is a rare TGCT (ie, it represents only 1% of testicular cancers) that is derived from mature germ ... Mar 1, 2025 ... A group of germ cells grows in a way that's not normal. A tumor forms. This usually happens in an ovary or testicle. Germ cell tumors in the testes of an adolescent male commonly present as an enlarging, solid mass, which may be painful. Within the ovaries, germ cell tumors ... Nov 30, 2020 ... Primordial germ cells (PGCs) are germline competent cells which form the functional gametes of the animal. The potential usage of avian PGCs ...