What are the potential for using germ cell-based therapies to treat genetic diseases that affect future generations?

Jun 8, 2006 ... Here we show that chicken PGCs can be isolated, cultured and genetically modified while maintaining their commitment to the germ line. Jan 8, 2004 ... We show that embryoid bodies support maturation of the primordial germ cells into haploid male gametes, which when injected into oocytes restore ... In a fetus, germ cells are cells that should become sperm in the testicles or eggs in the ovaries. Sometimes these cells don't travel to the right part of the ... Jun 12, 2024 ... RESULTS. Germ cell removal affects the life span of N. furzeri in a sex-dependent manner. To investigate the role of germ cells in ... Primordial germ cells in the mouse. Jan 16, 2024 ... Differential susceptibility of male and female germ cells to glucocorticoid-mediated signaling · Special Issue: Reproductive Health · Apical ... A type of cell that forms as a fetus (also called unborn baby or embryo) develops is called a germ cell. Germ cells are the cells that make the eggs (ova) in ... Apr 1, 2009 ... A fertilised egg is potentially immortal since it develops into a new organism that, in turn, can give rise to an endless series of generations. Cell. 1999 Jan 22;96(2):165-74. doi: 10.1016/s0092-8674(00)80557-7. Author. The initial step of spermatogenesis is the transition from male primitive germ cells (gonocytes) to undifferentiated spermatogonia in the neonatal testis.