How do mutations in specific genes disrupt germ cell development and function, leading to infertility or other reproductive disorders?

Jan 8, 2004 ... We show that embryoid bodies support maturation of the primordial germ cells into haploid male gametes, which when injected into oocytes restore ... Testicular germ cell metastatic BEP (bleomycin etoposide ciSplatin) EML. This protocol was published over 10 years ago and has been assessed by the reference ... Cell. 1999 Jan 22;96(2):165-74. doi: 10.1016/s0092-8674(00)80557-7. Author. Apr 11, 2018 ... Most types and stages of germ cell cancers of the ovary are treated the same way, with surgery and chemotherapy (chemo). Apr 1, 2009 ... A fertilised egg is potentially immortal since it develops into a new organism that, in turn, can give rise to an endless series of generations. Germ Cell Tumor Clinical Trials in Georgia. **Clinical trials are research studies that involve people. These studies test new ways to prevent, detect ... Jun 26, 2020 ... Most germ cell ovarian tumours are benign. These tumours are also called dermoid cysts or mature teratomas. Usually, the only treatment needed ... Growths that develop in egg cells are called ovarian germ cell tumors. These tumors may be benign (noncancerous) or malignant (cancerous). Extragonadal germ cell tumors have a variable clinical course, with the potential for aggressive behavior and widespread metastases. The imaging characteristics ... Germ cells are highly specialized cells with the unique ability of forming a new organism. This critical cell lineage is established very early on ...