How do maternal factors in the oocyte influence the development of the germline in the offspring?

We generated a gene-edited chicken, in which germ cells can be ablated in a drug-dependent manner, as recipients for gene-edited PGC transfer. Qiaolin Deng is studying this migration and maturation to learn more about infertility, epigenetic inheritance and cancer. Dec 17, 2024 ... AFP, β-hCG, or both are elevated in approximately 85% of extragonadal nonseminomatous germ cell tumors. Small increases in serum β-hCG can be ... CNS germ cell tumors typically form near the pineal gland or the pituitary gland, though they can form in other parts of the brain. The symptoms they produce ... Germ cells are forever. Cell. 2008 Feb 22;132(4):559-62. doi: 10.1016/j.cell.2008.02.003. ... germ cell function. The complex molecular regulation of sperm production and ... Reproduction.MS. Reproduction.MS seminar 'Mutational landscape and selective ... Cancers that develop from germ cells in other parts of the body are rare. The medical name for germ cell tumours that develop outside of the ovaries or ... Germ cells are the only cell type to give rise to the next generation in most animals. Despite this important function, how germ cell development is ... Jun 3, 2024 ... Germ cell exfoliation has been described as a predominant finding following administration of phthalate esters and microtubule inhibitors such as colchicine ... Germ-line cells are responsible for transmitting genetic information and for reproducing totipotency from generation to generation. Pluripotent stem cell lines, ...