How can we develop strategies to protect germ cells from environmental damage and mitigate the negative impacts on reproductive health?

The initial step of spermatogenesis is the transition from male primitive germ cells (gonocytes) to undifferentiated spermatogonia in the neonatal testis. Germ cell tumors in the brain can cause the following symptoms: Increased fluid in the brain (hydrocephalus)Hormonal imbalance, including early or delayed ... Germ cell tumors in the testes of an adolescent male commonly present as an enlarging, solid mass, which may be painful. Within the ovaries, germ cell tumors ... We investigated this phenomenon using live-cell imaging and discovered that ectopic germ cells preferentially induce body-wall muscle to extend cellular ... Testicular cancers start in germ cells. These are cells in the testicles that make sperm. These tumors often start in the testicles. Additionally, the Department of Animal Biology houses the Penn Vet Center for Animal Transgenesis and Germ Cell Research, which enables the genetic manipulation ... Benign extragonadal germ cell tumors are called benign teratomas. These tumors are usually diagnosed with imaging such as CT scans combined with blood tests but ... This is a malignant (cancerous) tumour formed from primitive germ cells (the reproductive cells of the body). Mar 1, 2025 ... A group of germ cells grows in a way that's not normal. A tumor forms. This usually happens in an ovary or testicle. GSCs divide asymmetrically leading to the formation of a self-renewing GSC and a differentiating cystoblast. The cystoblast then undergoes four rounds of ...