How can we develop better in vitro models of the germ cell microenvironment to study their interactions with somatic cells?

Tumors that start in specialized cells called germ cells. Symptoms include a lump, swelling, and/or pain in the affected body part, difficulty breathing, cough. Germ cell tumours of the central nervous system (CNS GCT) represent a heterogeneous group of neoplasms including germinoma, endodermal sinus tumour. (yolk sac ... Germ cell tumors (GCTs) are made up of these underdeveloped cells. These tumors are rare. They may be cancer (malignant) or not cancer (benign). May 17, 1990 ... We observed 16 cases of hematologic neoplasia associated with mediastinal germ-cell tumors. twenty-eight similar cases have been reported in the literature. In many animals, the germ cells originate in the primitive streak and migrate via the gut of an embryo to the developing gonads. There, they undergo meiosis, ... Additionally, the Department of Animal Biology houses the Penn Vet Center for Animal Transgenesis and Germ Cell Research, which enables the genetic manipulation ... Symptoms of germ cell tumors of the brain and spinal cord · Changes in endocrine function may cause: Slowed growth; Early or delayed puberty; Increased thirst ... Jan 16, 2008 ... Germ Cells Restrict Their Totipotent Potential. Germ cells are often described as the ultimate totipotent stem cell. However, germ cells give ... Most germ cell tumors are treated with chemotherapy along with radiation therapy. Chemotherapy Treatment Radiation therapy Surgery Jun 8, 2006 ... Here we show that chicken PGCs can be isolated, cultured and genetically modified while maintaining their commitment to the germ line.