How can germ cell research contribute to our understanding of aging and longevity?

Germ cell tumors in the testes of an adolescent male commonly present as an enlarging, solid mass, which may be painful. Within the ovaries, germ cell tumors ... In many animals, the germ cells originate in the primitive streak and migrate via the gut of an embryo to the developing gonads. There, they undergo meiosis, ... The Malignant Germ Cell International Consortium brings together the world's leading experts in germ cell tumors, from across the spectrum of cancer research. We investigated this phenomenon using live-cell imaging and discovered that ectopic germ cells preferentially induce body-wall muscle to extend cellular ... The initial step of spermatogenesis is the transition from male primitive germ cells (gonocytes) to undifferentiated spermatogonia in the neonatal testis. Jun 8, 2006 ... Here we show that chicken PGCs can be isolated, cultured and genetically modified while maintaining their commitment to the germ line. Apr 19, 2019 ... histologic subtypes share a common cell of origin. For example: – “Germ cell theory”: Primordial germ cells mismigrate during embryonic ... Dec 17, 2024 ... AFP, β-hCG, or both are elevated in approximately 85% of extragonadal nonseminomatous germ cell tumors. Small increases in serum β-hCG can be ... Germline is the sequence (lineage) of germ cells in a mature or developing organism that contains the genetic material that will be passed on to an offspring. Overview. A type of cell that forms as a fetus (also called unborn baby or embryo) develops is called a germ cell. Germ cells are the cells that make the ...