What are the ethical considerations related to prescription drug pricing and access?

... mg/20 mg tablet and after co-administration of the separate 145 mg fenofibrate and 20 mg simvastatin tablets as used in the clinical program, were within ... (n [ 739), 20 mg or less (n [ 920), or more than 20 mg. (n [ 1,284) ... that statins can be used for primary prevention of acute cardiovascular events ... ... use of the various statins between the groups (P = 0.81). For atorvastatin, the median dose was 30 mg (interquartile range 20–40 mg). Thus, the study dose ... Atorvastatin increased geometric mean fibrinogen by 12–20% vs. a 0–6% fall with simvastatin (p≪0.001). Side effects were noted in 10–36% of patients, including ... The aim of this study was to determine whether simvastatin 20 and 40 mg/d have an effect on systolic and diastolic blood pressure (SBP and DBP, respectively) Nov 1, 2009 ... ... mg or simvastatin 20 mg, 8,888, Major coronary event, including ... The JUPITER trial (Justification for the Use of statins in Primary ... that compared a statin to a statin with ER niacin 1000 mg added.68 Simvastatin 20 mg was the statin used by 93% of subjects. There were no differences in ... Jun 23, 2017 ... I started on Simvastatin at 20 mg but found that this gave me ... Nevertheless I decided to change to generic Atorvastatin 10mg as side effects ... Mar 18, 2019 ... The ambition is therefore that all people with a CVD risk of ≥20% should be prescribed this dose. For secondary prevention in people with pre- ... Nov 4, 2010 ... However, despite the substantial lipid-lowering associated with the use of statins, LDL-C reductions beyond that achieved by currently used ...