What are the recommended waiting periods when switching between different classes of antidepressants, considering their respective half-lives?

How Long Does it Take For Prozac (Fluoxetine) to work? Because of its long half-life (4 to 6 days), the initial impact arises within two weeks to about a month. Jun 15, 2024 ... Most SSRIs have a half-life of approximately one day, but Prozac's half-life is four to six days.1 This is important because withdrawal symptoms ... In general, manufacturers advise caution (prolonged half-life). Hepatic impairment For fluoxetine. Dose adjustments. Manufacturer advises dose reduction or ... Apr 13, 2025 ... This compound has double the half-life of fluoxetine and has a half-life of anywhere from 4 to 15 days. It can take months for the body to get ... The good effects of fluoxetine may, after a while, improve your sex life as your mood lifts and you become interested in life and relationships again. Some ... Fluoxetine (Prozac) used daily (B). Long half-life; agitation, insomnia, anorexia5. SSRI with shorter half-life (e.g., escitalopram. [Lexapro], sertraline [ ... Feb 17, 2023 ... Fluoxetine may still cause medicine interactions 5 or 6 weeks after stopping as fluoxetine and its active metabolite have a long half-life. Jan 4, 2023 ... ... fluoxetine, while paroxetine is appetite ... Due to its short half-life, paroxetine is not optimal for patients who might miss a dose. ... antidepressant and introducing fluoxetine. Conversely, because of the long half-life of fluoxetine and its metabolite, norfluoxetine, it is recommended that ... Apr 17, 2023 ... Prozac works by inhibiting the reuptake of serotonin, allowing it to stay in the brain for longer periods and enhancing its effects.