In the case of Prozac, how do the half-lives of fluoxetine and norfluoxetine contribute to the overall duration of action?

Discontinuation symptoms have been reported in association with selective serotonin reuptake inhibitors (SSRIs). Because of the long elimination half-life of ... Jan 3, 2020 ... Paxil (paroxetine) and Prozac (fluoxetine) are SSRI ... Prozac comes as a daily or weekly oral capsule and has a long half-life of 4 to 6 days. Apr 26, 2022 ... Fluoxetine has a half-life of 1–4 days and proved to be effective in the maintenance treatment of major depression and anxiety disorders ... According to the FDA, the elimination half-life of fluoxetine is 1 to 3 days after acute administration, and 4 to 6 days after chronic administration, with its ... Sep 12, 2024 ... Serotonin syndrome often resolves within 24 hours of discontinuing the serotonergic agent and initiating care, but drugs with long half-lives or ... Sep 24, 2022 ... Furthermore, in rodents, continuous administration of fluoxetine in drinking water corresponds better with the clinical situation since the half ... PO, metabolized in the liver primarily by CYP2D6, with fluoxetine (parent drug) having a half life of several day half life of 1-4 days · norfluoxetine is an ... Sertraline (Lustral®) – has a shorter half-life. The long half-life metabolite is only marginally active, unlike that in fluoxetine and hence is unlikely to ... May 3, 2022 ... It has a very long half-life (meaning it takes a long time for it to ... Infant blood levels of fluoxetine may reach more than half of maternal ... Jun 27, 2018 ... The half-life of Fluoxetine is about 2 to 7 days; however, norfluoxetine lasts longer with a half-life of 4 to 15 days. Fluoxetine stays in the ...