How does the route of administration (e.g., oral) affect Prozac's absorption and ultimately its half-life in terms of elimination?

Jun 15, 2024 ... Most SSRIs have a half-life of approximately one day, but Prozac's half-life is four to six days.1 This is important because withdrawal symptoms ... Apr 1, 2020 ... SSRIs like Paxil (paroxetine), which has a half-life of about one day, should be tapered down over a longer period than drugs like Prozac ( ... A sensitivity analysis found that removing responses involving fluoxetine, which has an especially long half-life, did not significantly alter this result. Jan 12, 2024 ... Despite its long-half life, symptoms associated with the discontinuation of PROZAC have been reported in clinical trials and post-marketing ... May 9, 2024 ... Side effects of both ... Prozac has a half-life that is longer than Lexapro's, which means it takes longer for Prozac to go through your body. Aug 12, 2022 ... This long half-life makes it easier to stop fluoxetine than some other antidepressants, which can cause withdrawal symptoms when you stop them ... Further, the elimination half life of it's active metabolite, norfluoxetine, ranges from 4-16 days after both acute and chronic administration. The half-life of ... Jun 20, 2024 ... Prozac is eliminated from the body slower than all other SSRIs, including Lexapro. This is described by the drug half-life (meaning the time it ... As most SSRIs have a half-life of around 24 hours, skipping doses creates large changes to drug levels, and so increases the risk and/or severity of withdrawal. Aug 1, 2016 ... Because Prozac's half-life is longer than Lexapro's, it takes longer to go through your body. Seniors tend to process drugs more slowly. A ...