How does Prozac's long half-life influence the approach to switching from an MAOI to Prozac?

Apr 21, 2025 ... Fluoxetine stays in your system longer (with a half-life of 2-7 days, depending on use patterns), resulting in Prozac withdrawal symptoms that ... The half-life of its active metabolite, norfluoxetine, is about 7 to 9 days. Metabolism: Fluoxetine is extensively metabolized in the liver to a desmethyl ... Jun 25, 2021 ... A randomized placebo-controlled clinical trial suggested that shorter half-life antidepressants may be at higher risk of withdrawal syndrome ... Mar 29, 2025 ... Fluoxetine has a long half-life, which can be a concern in certain patient populations, particularly older adults, due to its potential for ... Feb 17, 2023 ... Fluoxetine may still cause medicine interactions 5 or 6 weeks after stopping as fluoxetine and its active metabolite have a long half-life. May 3, 2022 ... It has a very long half-life (meaning it takes a long time for it to ... Infant blood levels of fluoxetine may reach more than half of maternal ... Jan 12, 2023 ... Prozac has a half-life that can range from 1-3 days depending on the amount of time the individual was on the drug. Longer-term usage of Prozac ... Elimination: The elimination half-life of fluoxetine is 4 to 6 days and for norfluoxetine 4 to 16 days. These long half-lives are responsible for persistence of ... Jul 1, 1997 ... ... half-life of fluoxetine and 7- to 9-day half-life of norfluoxetine. Bruising and bleeding disorders have also been described with fluoxetine use ... As most SSRIs have a half-life of around 24 hours, skipping doses creates large changes to drug levels, and so increases the risk and/or severity of withdrawal.