How does Prozac interact with other serotonergic drugs, increasing the risk of serotonin syndrome?

Apr 13, 2025 ... This compound has double the half-life of fluoxetine and has a half-life of anywhere from 4 to 15 days. It can take months for the body to get ... In general, manufacturers advise caution (prolonged half-life). Hepatic impairment For fluoxetine. Dose adjustments. Manufacturer advises dose reduction or ... Feb 17, 2023 ... Fluoxetine may still cause medicine interactions 5 or 6 weeks after stopping as fluoxetine and its active metabolite have a long half-life. Mar 29, 2025 ... Fluoxetine has a long half-life, which can be a concern in certain patient populations, particularly older adults, due to its potential for ... Hepatic. Elimination. Renal. Half-life (fluoxetine): 1–3 days (acute); 4–6 days (chronic) ... Feb 1, 2001 ... While it is true that fluoxetine's active metabolite has a half-life of up to 16 days, because of its low incidence of side effects compared ... The elimination half-life of fluoxetine is about 1 to 4 days, while that of its metabolite norfluoxetine ranges from 7 to 15 days. Fluoxetine has a nonlinear ... Jan 17, 2017 ... Fluoxetine has unique pharmacokinetic properties, probably what distinguishes fluoxetine from other SSRIs is its long half-life. Most SSRIs have ... Mar 6, 2021 ... Pharmacokinetics of Fluoxetine ; Primarily eliminated via hepatic metabolism to inactive metabolites, which are then excreted by the kidney. · 1 ... Aug 2, 2022 ... Then wait perhaps 1, 2, or more weeks for things to settle before the next cut. Expect withdrawal symptoms to emerge around the drug's half-life ...