What are the challenges and opportunities in developing new drugs for rare cancers like Ewing sarcoma

Ewing's sarcoma is a tumor made up of cancer cells that occurs in or around bone. It is the second most common type of bone cancer in children and adolescents. Jan 5, 2023 ... Study Reveals Inherited Risk Genes for Ewing Sarcoma ... A study led by Dana-Farber researchers has revealed that inherited variations in certain ... The EWS–ETS family of gene fusions and their downstream effects in Ewing's sarcomas provide opportunities for new approaches to treatment. These include the ... One of the most striking recurrent events found in our sequencing effort was mutations or rearrangements of the STAG2 gene. In further support of a functional ... May 27, 2022 ... Imaging plays an important role in the evaluation and management of ESFT, with MRI frequently the preferred imaging modality for primary tumor assessment and ... Mar 18, 2022 ... This study presented a case of ES/PNET, arising in the esophagus of a 21-year-old female patient presented with progressive dysphagia. Your child's care team will likely use several things to treat Ewing sarcoma ... Surgery to remove as much of the tumor as possible ... Chemotherapy Treatment ... Mar 31, 2024 ... Causes. Expand Section. Ewing sarcoma can occur anytime during childhood and young adulthood. But it usually develops during puberty, when bones ... Osteosarcoma and Ewing's sarcoma are malignant (cancerous) tumors that begin either in the bone or in the tissue around the bone. Ewing sarcoma is a rare type of cancer. It's most common in children and teens between the ages 10 and 19. It usually grows in bone.