How does the tumor microenvironment influence Ewing sarcoma growth and metastasis

Key Points: · Ewing's Sarcoma is a malignant small round blue cell tumor found mostly in bone and soft tissue of the extremities and the axial skeleton. Ewing's sarcoma is a tumor made up of cancer cells that occurs in or around bone. It is the second most common type of bone cancer in children and adolescents. Ewing sarcoma symptoms · A lump in the arm or leg bone · Pain in a bone · Swelling or warmth near a bone · Bone pain that does not get better over time or lasts ... Jul 5, 2018 ... Ewing sarcoma is a highly aggressive cancer, with a survival of 70-80% for patients with standard-risk and localized disease and ~30% for those with metastatic ... Ewing sarcoma is a type of cancer that grows in bones or in the soft tissue around bones. It often occurs in the leg, pelvis, ribs, or arm. The EWS–ETS family of gene fusions and their downstream effects in Ewing's sarcomas provide opportunities for new approaches to treatment. These include the ... 4 days ago ... Ewing sarcoma accounts for about 1% of childhood cancers in the United States, with roughly 200 new cases diagnosed annually, according to ... Localized Ewing sarcoma of the bone in children is usually treated with chemotherapy first. It may then be treated with surgery or radiation therapy. Treatment works best for children with localized tumors (when Ewing's sarcoma hasn't spread throughout the body). These children may have a 70 to 75% survival ... Jul 1, 2021 ... The board brings together a multidisciplinary group of specialists to review and discuss cases once a month. Its goal is to support physicians ...