What are some investigational EGFR-targeted therapies?

Apr 23, 2020 ... eGFR or Calculated Creatinine Clearance is a simple test to detect early changes in kidney function. A normal result means that kidney disease ... Jan 21, 2020 ... What Is the Risk of CA-AKI and CI-AKI in Patients Who Have eGFR Less Than 30, 30–44, 45–59, and Greater Than or Equal to 60 mL/Min/1.73 m2 ... Our study provides age- and gender-specific reference values of GFR in a population of Caucasian persons without identifiable risk. Mar 1, 2024 ... The Food and Drug Administration approved amivantamab-vmjw (Rybrevant, Janssen Biotech, Inc.) with carboplatin and pemetrexed for the first-line treatment of ... EGFR-positive non small cell lung cancer (NSCLC), a mutation, or damage, in a gene causes the EGFR to remain stuck in the “on” position. Sep 15, 2021 ... Abstract. Epidermal growth factor receptor (EGFR) mutations typically occur in exons 18–21 and are established driver mutations in non-small ... EGFR possesses kinase-independent (KID) pro-survival functions in cancer cells. This new knowledge has offered a different angle of understanding of EGFR in ... An EGFR mutation is the most common mutation for which there are treatments available. These new treatments, which are called targeted therapies, work directly ... Summary. EGFR mutation in lung cancer occurs due to a mutation in a person's EGFR protein. There are various subtypes of EGFR mutations. The type of EGFR ... EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell ...