How can high-resolution structures of EGFR inform the development of more effective therapies?

A mutation in the EGFR gene can be found in some people who have been diagnosed with non-small cell lung cancer (NSCLC). NSCLC with an EGFR mutation is known as ... Dec 20, 2021 ... The glomerular filtration rate, or GFR, measures how well your kidneys clean your blood. However, it's not just about getting rid of waste and extra water. EGFRvIII displays low-level constitutive signaling that is augmented by reduced internalization and downregulation. Aberrant EGFRvIII signaling has been shown ... What do the results mean? eGFR is reported in millilitres per minute (mL/min) and is written as “mL/min/1.73m2”. The “1.73m2” relates to body surface area. A ... Mar 6, 2020 ... An EGFR mutation test may be ordered by itself or as part of a panel (a series of tests to detect mutations in other genes such as KRAS, ALK and ... Protein names · Recommended name. Epidermal growth factor receptor. Curated · EC number. EC:2.7.10.1 (UniProtKB | ENZYME | Rhea ) · Alternative names. Proto- ... eGFR is an equation that uses your creatinine, age, and gender to see how well your kidneys are working. Alongside your eGFR, urine tests can help give a more accurate picture of how well your kidneys are working. Other tests. Sometimes other tests are also used to ... Aug 14, 2023 ... This prospective study characterized the clinical phenotype of patients and families with germline EGFR pathogenic variants (PVs). eGFR measures your kidneys' ability to filter toxins or waste from your blood. A very low number may indicate kidney failure, which requires dialysis or a ...