Can targeting the UPR modulate EGFR-driven cancers?

Mar 12, 2024 ... Is it good to have a high glomerular filtration rate? A GFR of 90 or higher is considered normal if you're healthy unless you have other ... Dec 4, 2019 ... A phase 3 trial compared first-line osimertinib with other EGFR-TKIs in patients with EGFR mutation–positive advanced non–small-cell lung cancer (NSCLC). Jan 28, 2025 ... EGFR inhibitors that target cells with either an exon 19 or exon 21 mutation: Drugs such afatinib (Gilotrif), erlotinib (Tarceva), dacomitinib ( ... Apr 1, 2025 ... Related Tests · The eGFR can show how well your kidneys are filtering your blood. · It is a calculation that represents the amount of blood ... Dec 23, 2023 ... What is EGFR (Glomerular Filtration Rate)? ... Delving into the intricate world of kidney health, the Glomerular Filtration Rate (EGFR) stands out ... Aug 14, 2023 ... This prospective study characterized the clinical phenotype of patients and families with germline EGFR pathogenic variants (PVs). What is EGFR-positive lung cancer? EGFR (epidermal growth factor receptor) is a gene that helps cells grow and survive. But when it mutates, it can... What does an eGFR test result mean? · An eGFR below 60 for three months or more, or an eGFR above 60 with kidney damage (marked by high levels of albumin in ... Apr 5, 2021 ... What is EGFR-mutant lung cancer? A mutation in the gene EGFR, which stands for epidermal growth factor receptor, causes cells to grow without ... Aug 16, 2024 ... eGFR measures how well your kidneys are functioning. It measures your kidneys' ability to filter waste and toxic components from the blood.