What are the potential ethical challenges of adaptive double-blind trials?

May 10, 2021 ... We report the findings of a randomized, double-blind, placebo-controlled, multi-site phase 3 clinical trial (NCT03537014) to test the efficacy ... The purpose of this research trial is to investigate the effects of LY3437943 (drug) compared with placebo on renal function, in participants who are ... ... trials. We conducted a randomized, double-blinded, 7 arm clinical trial to: (1) identify the presence of a dose-response for complete protection from emesis ... Jan 23, 2025 ... This prospective, double-blind, test accuracy study was designed to test whether an artificial intelligence (AI)–guided software device (AutoDVT) could support ... Randomized double blind placebo control (RDBPC) studies are considered the “gold standard” of epidemiologic studies. A Phase 3, Multicenter, Randomized, Placebo-controlled, Double-blind Study to Evaluate the Efficacy and Safety of Lanadelumab for Prevention Against Acute ... The results suggest that in a subset of patients, physostigmine can induce a degree of cognitive improvement over 6 weeks of treatment. Seizures were controlled in 89% of the episodes treated with lorazepam and in 76% treated with diazepam. The times for onset of action of the medications did ... Nov 9, 2018 ... A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with ... Abstract. In a double-blind trial in 21 patients with spasmodic torticollis botulinum-A toxin produced both subjective and objective improvement, including ...