How can pragmatic clinical trials incorporate elements of blinding?

Feb 10, 2021 ... Methods. In this double-blind trial, we enrolled 1961 adults with a body-mass index (the weight in kilograms divided by the square of the ... ... double-blind study of adjuvant pembrolizumab (pembro) with V940 (mRNA-4157) or placebo for renal cell carcinoma (RCC). Based on the phase 3 KEYNOTE-564 trial ... Vaccine trials are typically tested through a study design called a randomized, double-blind and placebo-controlled trial. This means that participants are ... A double blind study is a randomized clinical trial in which only those directing the study know the treatment that each participant receives. In this short-term study, romiplostim increased platelet counts in 88% of children with ITP and was well-tolerated and apparently safe. The safety/tolerability of clopidogrel (plus aspirin) is superior to that of ticlopidine (plus aspirin) (P=0.005). The 300-mg loading dose was well tolerated. A double-blind, randomized, prospective study was undertaken to determine if the dose of OKT3 used for induction immunosuppression following kidney and ... Nov 18, 2012 ... A Double-Blind Study Comparing Enalapril and Hydrochlorothiazide as Single Agents in the First-Line Therapy of Mild to Moderate Essential ... Double-Blind Study pronounce term ... A type of clinical trial in which neither the participants nor the research team know which treatment a specific participant ... A Phase 3, Multicenter, Randomized, Placebo-controlled, Double-blind Study to Evaluate the Efficacy and Safety of Lanadelumab for Prevention Against Acute ...