How are the rights and welfare of participants protected in double-blind studies?

A clinical trial design in which neither the participating individuals nor the study staff knows which participants are receiving the experimental drug and ... May 10, 2021 ... We report the findings of a randomized, double-blind, placebo-controlled, multi-site phase 3 clinical trial (NCT03537014) to test the efficacy ... Feb 10, 2021 ... Methods. In this double-blind trial, we enrolled 1961 adults with a body-mass index (the weight in kilograms divided by the square of the ... A decentralized, Phase 2, randomized, double-blind study of Nirmatrelvir/Ritonavir compared with placebo/Ritonavir for long COVID. Nov 9, 2018 ... A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with ... Seizures were controlled in 89% of the episodes treated with lorazepam and in 76% treated with diazepam. The times for onset of action of the medications did ... The results suggest that in a subset of patients, physostigmine can induce a degree of cognitive improvement over 6 weeks of treatment. Upon receipt of the test material, researchers will record the date of receipt on their copy of DEA Form 222, or attach the documentation to their retained Copy ... ... double-blind study of adjuvant pembrolizumab (pembro) with V940 (mRNA-4157) or placebo for renal cell carcinoma (RCC). Based on the phase 3 KEYNOTE-564 trial ... Rituximab depletes B cells and may reduce the production of autoantibodies against PLA2R or THSD7A. Therefore, the measurement of autoantibodies in participants ...