What is the role of p53 in response to S phase stress?

Oct 7, 2014 ... ... cells were in G0/G1 phase under physiological conditions (Fig. 1C). There were no significant differences in cell cycle status (G0/G1, S ... Jan 29, 2024 ... Metastasis in ovarian cancer typically occurs through three ... induces apoptosis and cell cycle arrest at the S phase in. SKOV-3 ... Apr 1, 2019 ... We show here that small molecule 2-[(3,4-dihydroquinolin-1(2H)-yl)(p-tolyl)methyl]phenol (THTMP), a potential anticancer agent, increases the human ... Jul 8, 2008 ... Cyclin D/CDdk4–Cdk6 activity occurs in mid-late G1 phase, upstream of Cdk2/cyclin E activity. Under conditions favouring proliferation, the ... The 5-bromo-2′-deoxyuridine (BrdU) labeling of cells followed by antibody staining has been the standard method for direct measurement of cells in the ... During G1 phase, growth-dependent cyclin-dependent kinase (CDK) activity promotes DNA replication and initiates G1-to-S phase transition. Mar 30, 2021 ... In addition, caspase-2-deficient cells have a higher frequency of stalled replication forks, decreased DNA fiber length, and impeded progression ... *(This usually occurs with mitosis, but in some organisms this is not so.) M-Phase (mitosis + cytokinesis). The events of eukaryotic cell division image 2 *( ... May 1, 2008 ... This indicates nuclear DNA synthesis occurs during development. Mitosis and early S phase were both twofold longer in slugs as compared with ... Oct 31, 2023 ... ... cell in either G2M, S or G1 phase. CellCycleScoring() can also set the identity of the Seurat object to the cell-cycle phase by passing set.