What are the different types of DNA damage that can occur during replication and how are they repaired?

Furthermore, the cell-cycle phase may directly regulate DNA end resection as resection occurs fastest in S phase and CtIP-dependent resection is upregulated by ... Mar 24, 2025 ... The cell cycle is a four-stage process in which the cell increases in size (gap 1, or G1, stage), copies its DNA (synthesis, or S, stage), prepares to divide ( ... Actively dividing eukaryote cells pass through a series of stages known collectively as the cell cycle: two gap phases (G1 and G2); an S (for synthesis) ... The S phase, occurring between the G1 and G2 phases of the cell cycle, is when DNA replication and much of the DNA repair activity occurs in cells. Apr 1, 2019 ... We show here that small molecule 2-[(3,4-dihydroquinolin-1(2H)-yl)(p-tolyl)methyl]phenol (THTMP), a potential anticancer agent, increases the human ... Background & Aims: The G1/S-phase controlling mechanism known as the RB pathway is commonly deregulated in human malignancies. Here, the abundance and ... What occurs during the S phase of the cell cycle? 1) the genetic material is copied, 2) chromosomes replicate and become double stranded chromatids. May 29, 2015 ... We present a tool to identify cell cycle phases and in particular, sub-stages of the DNA replication phase (S-phase) based on the characteristic patterns of ... H. Stuck in division or passing through: what happens when cells ... C. CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage. During interphase, G1 involves cell growth and protein synthesis, the S phase ... phase, of interphase during which DNA replication occurs. telophase: the ...