What are potential therapeutic strategies for targeting cancer cells with inherent defects in DNA replication or S phase checkpoints?

Dec 16, 2021 ... In the G2 phase the cell is in the last phase before it officially divides. The cell in the G2 also increases in size much more and goes through ... The 5-bromo-2′-deoxyuridine (BrdU) labeling of cells followed by antibody staining has been the standard method for direct measurement of cells in the ... Mar 30, 2021 ... In addition, caspase-2-deficient cells have a higher frequency of stalled replication forks, decreased DNA fiber length, and impeded progression ... May 12, 2016 ... interphase (in between divisions phase grouping G1 phase, S phase, G2 phase), during which the cell is ... What does S stand for and what occurs ... Then, at a critical point during interphase (called the S phase), the cell duplicates its chromosomes and ensures its systems are ready for cell division. If ... E.g. antimetabolites such as methotrexate work in the S phase (synthesis phase) of the cell cycle. Intravenous antineoplastic drugs are administered in the ... Sep 11, 2017 ... Western blot assay was used to detect the levels of cell cycle and apoptosis related proteins. Xenografts in nude mice were used to evaluate the ... Dec 26, 2024 ... ... S phase and next cell division event the G2 phase ... phases of the cell cycle but also what specifically occurs during the different phases. Actively dividing eukaryote cells pass through a series of stages known collectively as the cell cycle: two gap phases (G1 and G2); an S (for synthesis) ... (2010). A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression. PLoS ...