What are common fragile sites in the human genome and why are they prone to breakage during DNA replication?

In the first phase (G1) the cell grows and becomes larger. When it has reached a certain size it enters the next phase (S), in which DNA-synthesis takes place. In order to ensure that replication occurs only once per cell cycle, geminin inhibits and destabilizes CDT1 during the S, G2 and M phases. At the metaphase/ ... *(This usually occurs with mitosis, but in some organisms this is not so.) M-Phase (mitosis + cytokinesis). The events of eukaryotic cell division image 2 *( ... ... in the mother cell or a single nucleus arrested in the isthmus between the mother cell and the daughter bud. Exposure of unbudded stationary-phase cells to ... occurs. In principle, th this pathway operation. Central to and probab ... to those seen late in S and G2 phases of the cell cycle. It is not clear at ... In fact, the accumulation of cells in S phase was found to be a gradual process that occurs over several cell cycles, as shown in Fig. 2 B for ... The S phase, occurring between the G1 and G2 phases of the cell cycle, is when DNA replication and much of the DNA repair activity occurs in cells. Dec 18, 2006 ... This suppression during S phase is apparently regulated by cell cycle position alone and occurs automatically during each cell cycle. If the ... Mar 30, 2021 ... In addition, caspase-2-deficient cells have a higher frequency of stalled replication forks, decreased DNA fiber length, and impeded progression ... May 10, 2023 ... The S phase of a cell cycle occurs during interphase, before mitosis or meiosis, and is responsible for the synthesis or replication of DNA.