How does the cell handle topological stress generated during DNA unwinding?

Actively dividing eukaryote cells pass through a series of stages known collectively as the cell cycle: two gap phases (G1 and G2); an S (for synthesis) ... May 13, 2018 ... Sinomenine, a bioactive alkaloid isolated from the traditional Chinese herb Sinomenium acutum, possesses antiinflammatory, antinociceptive, ... Jul 10, 2020 ... ... occurs at the K430 site (Fig. 2GOpens in ... Chen, BRCA1 modulates the autophosphorylation status of DNA-PKcs in S phase of the cell cycle. The 5-bromo-2′-deoxyuridine (BrdU) labeling of cells followed by antibody staining has been the standard method for direct measurement of cells in the ... occurs. In principle, th this pathway operation. Central to and probab ... to those seen late in S and G2 phases of the cell cycle. It is not clear at ... Members of the Bcl-2 family play a major role in the patho-biology of head and neck cancer ... cycle and survival of endothelial cells and HNSCC and on the ... Aug 14, 2008 ... In this study, we show that miR-17-92 is a cell cycle regulated locus, and ectopic expression of a single microRNA (miR-17-5p) is sufficient to ... Dec 18, 2006 ... This suppression during S phase is apparently regulated by cell cycle position alone and occurs automatically during each cell cycle. If the ... Jan 8, 2018 ... ... cell cycle bias and preferentially occurs during the S phase. ORF2p binds chromatin and localizes at replication forks with PCNA during S phase. Feb 5, 2018 ... In this phase, the cell starts accumulating all the proteins required for its division and grows in size. The duration of this phase in the cell ...