How do mechanical forces and the physical properties of the nucleus influence DNA replication and genome integrity?

What occurs during the S phase of the cell cycle? 1) the genetic material is copied, 2) chromosomes replicate and become double stranded chromatids. Jun 26, 2023 ... However, exactly how highly expressed UCP2 regulates cell proliferation, cell cycle, and cell death during the early stage of tumorigenesis has ... Mar 24, 2025 ... The cell cycle is a four-stage process in which the cell increases in size (gap 1, or G1, stage), copies its DNA (synthesis, or S, stage), prepares to divide ( ... Oct 25, 2011 ... ... during late mitosis and G to license replication origins for use in S phase. ... cell cycle in Chinese Hamster Ovary (CHO) cells. We find that ... The eukaryotic cell spends most of its "life" in interphase of the cell cycle, which can be subdivided into the three phases, G1, S and G2. Cell division is ... Members of the Bcl-2 family play a major role in the patho-biology of head and neck cancer ... cycle and survival of endothelial cells and HNSCC and on the ... During G1 phase, growth-dependent cyclin-dependent kinase (CDK) activity promotes DNA replication and initiates G1-to-S phase transition. ... during the S-Phase of the cell cycle. Measurement of DNA synthesis is therefore essential for research in many scientific fields, such as assessing cell ... S phase (Synthesis phase) is the phase of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase. Since accurate duplication of ... Furthermore, the cell-cycle phase may directly regulate DNA end resection as resection occurs fastest in S phase and CtIP-dependent resection is upregulated by ...