How can we harness the power of stem cell biology to study the S phase in different developmental contexts?

1 expression and S-phase progression provides a “synchromesh” mechanism that “locks” the erythroid differentiation program to the cell cycle clock, ensuring ... E.g. antimetabolites such as methotrexate work in the S phase (synthesis phase) of the cell cycle. Intravenous antineoplastic drugs are administered in the ... The S phase, occurring between the G1 and G2 phases of the cell cycle, is when DNA replication and much of the DNA repair activity occurs in cells. In order to ensure that replication occurs only once per cell cycle, geminin inhibits and destabilizes CDT1 during the S, G2 and M phases. At the metaphase/ ... Jan 11, 2013 ... The correlations between Mirk/Dyrk1B expression and active ERK1/2 detected by western blot in both ovarian cancer and non-small cell lung cancer ... Jan 8, 2018 ... ... cell cycle bias and preferentially occurs during the S phase. ORF2p binds chromatin and localizes at replication forks with PCNA during S phase. Jan 11, 2021 ... Although CDK4/6 inhibitors are an established treatment for hormone receptor–positive, HER2-negative metastatic breast cancers, their benefit in ... 32 What happens during the S phase? DNA synthesis or replication. 33 Each chromosome originally is made of how many DNA molecules and how does this molecule ... Mar 30, 2021 ... In addition, caspase-2-deficient cells have a higher frequency of stalled replication forks, decreased DNA fiber length, and impeded progression ... What occurs during the S phase of the cell cycle? 1) the genetic material is copied, 2) chromosomes replicate and become double stranded chromatids.