How can we design novel tools to track and manipulate replication forks in living cells?

E.g. antimetabolites such as methotrexate work in the S phase (synthesis phase) of the cell cycle. Intravenous antineoplastic drugs are administered in the ... The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK). Chromosome duplication occurs during S phase of the cell cycle, whereas most other cell components are duplicated continuously throughout the cycle. During M ... A cell moves through a series of phases in an orderly manner. During interphase, G1 involves cell growth and protein synthesis, the S phase involves DNA ... Sep 11, 2017 ... Western blot assay was used to detect the levels of cell cycle and apoptosis related proteins. Xenografts in nude mice were used to evaluate the ... Dec 6, 2022 ... During the G1 phase, also known as the first gap phase, the cell becomes physically larger, copies organelles, and produces the molecular ... Aug 31, 2020 ... ... S phase cell cycle block via p21 upregulation. In: Immunity, inflammation and disease. 2020 ; Vol. 8, No. 4. pp. 568-583. @article ... Jul 11, 2022 ... ]. The periodic expression of cell cycle regulators occurs in two broad waves of expression, which peak during the G1/S and G2/M phase ... Members of the Bcl-2 family play a major role in the patho-biology of head and neck cancer ... cycle and survival of endothelial cells and HNSCC and on the ... May 29, 2015 ... We present a tool to identify cell cycle phases and in particular, sub-stages of the DNA replication phase (S-phase) based on the characteristic patterns of ...