Can interventions that promote healthy S phase progression have broad benefits for aging and age-related diseases?

Then, at a critical point during interphase (called the S phase), the cell duplicates its chromosomes and ensures its systems are ready for cell division. If ... Mar 30, 2021 ... In addition, caspase-2-deficient cells have a higher frequency of stalled replication forks, decreased DNA fiber length, and impeded progression ... (2010). A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression. PLoS ... Apr 25, 2013 ... In the S phase (synthesis phase), DNA replication results in the formation of two identical copies of each chromosome—sister chromatids—that are ... Cells prepare for DNA replication in S phase by loading MCMs at replication origins in the preceding G1 phase, a process called “origin licensing.” The amount ... Jan 22, 2003 ... Vascular endothelial cell (VEC) proliferation is a key event in angiogenesis and is tightly regulated. Electric potential differences exist ... Apr 1, 2019 ... We show here that small molecule 2-[(3,4-dihydroquinolin-1(2H)-yl)(p-tolyl)methyl]phenol (THTMP), a potential anticancer agent, increases the human ... In order to ensure that replication occurs only once per cell cycle, geminin inhibits and destabilizes CDT1 during the S, G2 and M phases. At the metaphase/ ... Jan 8, 2018 ... ... cell cycle bias and preferentially occurs during the S phase. ORF2p binds chromatin and localizes at replication forks with PCNA during S phase. S phase (Synthesis; when the copying of DNA happens). ... These attack cancer cells during specific phases of the cell cycle, but never during the resting phase.