Can errors in DNA replication lead to aneuploidy?

Oct 13, 2019 ... In G1-phase cells are growing and preparing for DNA replication. The DNA replication thereafter takes place during S-phase, where the cellular ... The S phase, occurring between the G1 and G2 phases of the cell cycle, is when DNA replication and much of the DNA repair activity occurs in cells. ... in the mother cell or a single nucleus arrested in the isthmus between the mother cell and the daughter bud. Exposure of unbudded stationary-phase cells to ... Mar 24, 2025 ... The cell cycle is a four-stage process in which the cell increases in size (gap 1, or G1, stage), copies its DNA (synthesis, or S, stage), prepares to divide ( ... We have shown that CS exerts an inhibitory effect on the proliferation of MDA-MB-231, MCF-7 and T47D breast cancer cells in a dose and time-dependent manner. The G0/G1 and G2/M curves are fit using the same process as the Watson model. The difference occurs in the fit of the S phase. The Dean-Jett model fit a second ... It is generally believed that this type of repair occurs preferentially in the late S, G2 and M phases of the cell cycle, when the sister chromatid is ... Furthermore, the cell-cycle phase may directly regulate DNA end resection as resection occurs fastest in S phase and CtIP-dependent resection is upregulated by ... ... phase become less radiosensitive than they are in other phases of the cell cycle. This paper is only available as a PDF. Keywords. Granulocyte/macrophage ... Actively dividing eukaryote cells pass through a series of stages known collectively as the cell cycle: two gap phases (G1 and G2); an S (for synthesis) ...