What are the cellular and molecular pathways affected by the increased gene dosage in Down syndrome?

Down's syndrome is the commonest identifiable cause of intellectual disability, accounting for around 15-20% of the intellectually disabled population. It is ... Down syndrome is caused by an extra chromosome, either a partial or full extra chromosome, on chromosome 21. The extra chromosome will affect how a baby's body ... Aug 15, 2000 ... Down syndrome (trisomy 21) is the most commonly recognized genetic cause of mental retardation. The risk of trisomy 21 is directly related ... Cerebral palsy is a neurological condition that usually occurs at birth and causes physical disabilities. Down syndrome is a chromosomal abnormality that causes ... Down syndrome is the most common genetic cause of intellectual disability, affecting approximately 1 in every 700 children. It is named for John Langdon Down, ... Down syndrome is a genetic condition caused by extra copies of chromosome 21. It results in certain characteristics, including some degree of cognitive ... Feb 17, 2022 ... Congenital Heart Defects affect approximately 50% of babies born with Down syndrome. Learn more about causes, common types, and treatments. Apr 12, 1994 ... In addition, Dr. Lejeune was a pioneer in clinical cytogenetics and carried out numerous clinical and biochemical studies of people with Down ... Down syndrome is a genetic disorder. It includes certain birth defects, learning problems, and facial features. A child with Down syndrome also may have heart ... Oct 22, 2004 ... The “Down syndrome critical region” (DSCR) is a chromosome 21 segment purported to contain genes responsible for many features of Down ...