Are there any naturally occurring or experimental compounds that can modulate the expression or function of these key genes?

This work underlines a Pcp4-dependent ciliopathy in Down syndrome brain affecting cerebrospinal fluid flow. Oct 7, 2021 ... The main causes of death were pneumonia/respiratory infections (20.5%), congenital malformations of the circulatory system (11.2%), other diseases of the ... Fetuses with Down syndrome have an extra copy of chromosome 21, resulting in 47 chromosomes total. This excess genetic material causes the physical and mental ... Aug 8, 2023 ... Down syndrome (trisomy 21) is a genetic disorder caused by the presence of all or a portion of a third chromosome 21. Down's syndrome is the commonest identifiable cause of intellectual disability, accounting for around 15-20% of the intellectually disabled population. It is ... Feb 16, 2024 ... What causes Down syndrome? En Español. Down syndrome is caused by a random error in cell division that results in the presence of an extra copy ... Down syndrome is the most frequently occurring chromosomal disorder and the leading cause of intellectual and developmental delay in the US and in the world. Trisomy 21– More than 90% of Down syndrome cases are caused by trisomy 21. An extra chromosome (chromosome 21) originates in the development of either the sperm ... This extra genetic material causes the physical features and developmental delays in people with Down syndrome. The features are no different if the extra ... Jul 16, 2009 ... The research sheds light on the genetic underpinnings of aneuploidy, a condition marked by having an abnormal number of chromosomes.