Genomic Databases What are the potential impacts of mutations in stop codons on protein function and disease?

Feb 6, 2025 ... ... three stop codons that terminate protein production. The recoded genome reassigned four codons to non-degenerate functions, including the ... BELIN, Dominique, PUIGBO, Pere. Why is the UAG (amber) stop codon almost absent in highly expressed bacterial genes? In: Life, 2022, vol. 12, n° 3, p. 431. Nov 22, 2023 ... The stop codon is the last three bases of the coding sequence, not of the exon per transcript, as there are untranslated exons (5'- and 3 ... ... (3), Hiroyuki Araki(4), Yasuji Oshima(5) (1) (2) (3) (4) (5) (*) Corresponding Author. Abstract. The smp3-1 mutant allele confers increased holding stability ... May 2, 2023 ... A stop codon is a trinucleotide sequence of three nucleotides found in messenger RNA (mRNA) or DNA that instructs the cell to stop production of ... In molecular biology, a stop codon (or termination codon) is a codon that signals the termination of the translation process of the current protein. STOP codons. There are 3 STOP codons in the genetic code - UAG, UAA, and UGA. These codons signal the end of the polypeptide chain during translation. These ... Apr 27, 2011 ... These results suggest that 3′ RNA stimulatory structures feature in a much larger proportion of readthrough cases than previously anticipated. Jul 24, 2023 ... replication, we first replaced the arginine codon with each of the three stop codons in ... 3' of the stop codon disrupted TR of the SINV opal ... May 29, 2018 ... ... three stop codons (Du et al., 2013). However, the mechanism of their action remains unknown. New readthrough compounds have also been found ...