EF-G How do stop codons function in the context of synthetic mRNA therapeutics, such as mRNA vaccines?

eRF1/3, = eukaryotic release factor 1/3 ; NTC, = normal termination codon ; PABP, = poly(A)-binding proteins ; RT, = STOP codon readthrough ; PTC, = premature ... May 2, 2023 ... A stop codon is a trinucleotide sequence of three nucleotides found in messenger RNA (mRNA) or DNA that instructs the cell to stop production of ... Aug 6, 2015 ... In cells, all proteins are produced by ribosomes that 'read' messenger RNA (mRNA) one codon, or three nucleotides, at a time. Protein ... Nov 3, 2023 ... Novel Ciliate Genetic Code Variants Including the Reassignment of All Three Stop Codons to Sense Codons in Condylostoma magnum. Molecular ... ... (3), Hiroyuki Araki(4), Yasuji Oshima(5) (1) (2) (3) (4) (5) (*) Corresponding Author. Abstract. The smp3-1 mutant allele confers increased holding stability ... Jun 29, 2010 ... For four decades after the discovery of the release factors, three fundamental questions concerning the mechanism of translation termination. ... three stop codons), in eukaryotes (2–4) (Fig. 1A). However, the mechanism of stop codon recognition by release factors is unknown and represents a long ... Nov 3, 2020 ... The three stop codons in mRNA are UAA, UAG, and UGA, where U stands for uracil, A for adenine, and G for guanine. Stop codons provide an end ... Dec 1, 2020 ... Our analysis reveals no evidence of stop codon reassignment for peritrichs, but they have prevalent +1 or -1 PRF events. In this study, we used hA3A-BE3-Y130F to simultaneously introduce premature stop codons (TAG, TGA, and TAA) into three tumor suppressor genes, TP53, PTEN, and ...