Developmental Biology What are the mechanisms that prevent ribosomes from prematurely terminating translation at internal stop codons within an open reading frame?

... three triplets act as 'stop codons' and signal the end of the protein. The genetic code is the link between triplet codons and amino acids. The 'decoding ... All protein-coding regions begin with the "start" codon, ATG. There are three "stop" codons that mark the end of the protein-coding region. Multiple codons can ... Nov 3, 2023 ... Novel Ciliate Genetic Code Variants Including the Reassignment of All Three Stop Codons to Sense Codons in Condylostoma magnum. Molecular ... In this study, we used hA3A-BE3-Y130F to simultaneously introduce premature stop codons (TAG, TGA, and TAA) into three tumor suppressor genes, TP53, PTEN, and ... Mar 16, 2005 ... In most organisms, one of three stop codons (UAA, UAG and UGA) signals the termination of protein translation. Occasionally a near-cognate tRNA ... ... [3,4]. By this method, a number of genes containing am- ber, ochre, or opal ... stop codon of the wild type. ADH gene is resistant to suppression by a ... Jun 18, 2018 ... Each of the three stop codons, UAA, UGA and UAG, is used in all three domains of life, with occasional reassignment of stop codons for amino ... Jun 22, 2012 ... We find that m(6)A sites are enriched near stop codons and in 3' UTRs, and we uncover an association between m(6)A residues and microRNA-binding sites within 3 ... Apr 27, 2011 ... These results suggest that 3′ RNA stimulatory structures feature in a much larger proportion of readthrough cases than previously anticipated. Nov 22, 2023 ... The stop codon is the last three bases of the coding sequence, not of the exon per transcript, as there are untranslated exons (5'- and 3 ...