What is the role of platelets in sepsis?

Coagulation disorders can result in either too little blood clotting (hemorrhage) or too much blood clotting (thrombosis). Apr 1, 2025 ... Mature, anucleate platelets contain not only messenger RNA transcripts as well as the necessary machinery to conduct translation, but also ... My research interests are centered around platelet signaling and function. More specifically, I am focused on two main areas of platelet research. May 10, 2024 ... Platelets contribute to inflammation via surface receptors, release of mediators, and participation in neutrophil extracellular trap formation. We research how megakaryocytes make blood platelets, and the role(s) that these platelets play in different disease states. Oct 1, 2017 ... We therefore compared platelet function and parameters of apoptosis and clearance of untreated and IBS-treated human platelets in a large number ... Most in vitro studies examining the role of flow shear stress on platelets have utilized blood from healthy young or middle-aged adults. Platelets from newborns ... The P2Y 12 receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y 12 receptor antagonists that have proven ... The program will include sessions on platelet biogenesis, platelet function/activation, platelets and coagulation, platelets and disease, and emerging trends in ... During your PhD at the University of Reading, you will expand your research knowledge and skills, receiving supervision in one-to-one and small group sessions.