What are the implications of altered cholesterol and sphingolipid metabolism in disease?

... lipids, proteins, and nucleic acids), let's talk about macromolecules as a whole. Each is an important cell component and performs a wide array of functions. ApoE is produced in abundance in the brain and serves as the principal lipid transport vehicle in CSF. It is induced at high concentration in peripheral nerve ... Jan 24, 2024 ... They act as messengers, helping proteins do their jobs. They also start chemical reactions that help control growth, immune function, ... Apr 1, 2024 ... In the heart, GLP-1 binding to its receptor enhances myocardial performance and has important physiological effects on cardiac function through ... Lipids are classified as those organic compounds which do not interact with water. Put in simple terms, most substances made of lipids will not be miscible ... Dec 16, 2022 ... Endolysosomal membrane dynamics and function are controlled by phosphoinositide signaling lipids, most notably by the synthesis and turnover ... Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of lipids called fats. Lipids also provide insulation ... Mar 1, 2018 ... The auto-correlation functions for interfacial hydrogen bonded networks develop humps during a transition from cage-like motion to eventual ... May 30, 2020 ... This study investigated differences in vascular function, lipids, body composition, and physical fitness in elderly postmenopausal women active in combined ... May 18, 2022 ... The functions of seipin in triacylglycerol nucleation and lipid droplet maturation are studied with all-atom and coarse-grained simulations ...