What are the different approaches being investigated for hair cell regeneration (e.g., gene therapy, stem cell therapy, drug development)?

... stereocilia in the auditory system and no kinocilium -which are ... Therefore the correct term to be used is stereocilium/ stereocilia and not Kinocilia? We previously reported that CIB2 binds to WHRN and is essential for stereocilia staircase architecture of cochlear hair cells. Here, we refine the ... Jun 20, 2019 ... We report that TRIOBP-5 is essential for thickening bundles of F-actin in rootlets, establishing their mature dimensions and for stiffening supporting cells. The actin filament bundle, which is held together by specific crossbridges, gives rigidity and exact dimensions to each stereocilium. The cuticular plate ... They have more stereocilia and long stereocilia relative to kinocilia heights. Tip link tensions show parallel behavior in peripheral columns of the bundle ... Cilium (plu: cilia) is an organelle that is short and filament-like. It looks like an eyelash that protrudes from eukaryotic cells, and can be motile or non- ... The organ of Corti contains tiny hair cells with stereocilia at the ends. Stereocilia are delicate, hair-like projections that react to cochlea fluid movement. Aug 23, 2016 ... Abstract. Stereocilia are actin-based protrusions on auditory and vestibular sensory cells that are required for hearing and balance. They ... They are distinct from cilia and microvilli, but are closely related to microvilli. They form single "finger-like" projections that may be branched, with normal ... Jan 25, 2016 ... ... stereocilia. While functionally very different, the protein complexes that organize microvilli and stereocilia have striking parallels. Both ...