What are the conserved genes and pathways involved in stereocilia development across different species?

The actin filament bundle, which is held together by specific crossbridges, gives rigidity and exact dimensions to each stereocilium. The cuticular plate ... Jul 21, 2022 ... Sensorineural Hearing Loss. Inside the inner ear is the cochlea, which is lined with tiny hair cells called stereocilia that convert soundwaves ... May 10, 2021 ... We show that IHC and OHC stereocilia are similarly TM-embedded and that Ca 2+ ducts connect the TM to the stereocilia of IHCs and OHCs. Apr 16, 2025 ... Stereocilia perch atop sensory hair cells in the inner ear. Source: Yoshiyuki Kawashima. Most NIHL is caused by the damage and eventual death of ... Apr 13, 2017 ... Because the actin filaments in the stereocilia of hair borders still remain as compact bun- dles, albeit very disordered, there must be an addi-. PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing. Nature Comm. 10: 3801. 153. György, B., Nist-Lund, C., Pan, B., Asai ... ... stereocilia of regimented lengths and a single microtubule-based kinocilium. ... We have developed a large-scale purification method that enriches stereocilia ... They are distinct from cilia and microvilli, but are closely related to microvilli. They form single "finger-like" projections that may be branched, with normal ... Jul 8, 2022 ... Inside the inner ear is the cochlea, which is lined with tiny hair cells called stereocilia. The stereocilia's job is to convert sound waves ... May 24, 2023 ... Stereocilia are miniscule hair-like protrusions on the surface of sensory cells (also called hair cells) found deep within the cochlear and ...