What are the challenges in achieving functional hair cell regeneration in humans?

Feb 22, 2024 ... Loud noise is causing zinc, normally localized to stereocilia, to be blasted over many Zinc in the inner ear is concentrated in stereocilia ... Jul 1, 1980 ... From our results, we conclude that the stereocilia of the ear, unlike the brush border of intestinal epithelial cells, are not designed to ... Apr 21, 2025 ... Cilia are made of microtubules, while stereocilia and microvilli are made of actin filaments. The shortest is microvilli, intermediate height ... Jan 4, 2021 ... show that ADF/cofilin-1 are recruited to mechanotransducing auditory stereocilia tips, where they increase the availability of F-actin barbed. Feb 9, 2022 ... These cells possess stereocilia connected to the tectorial membrane. ... During auditory stimulation, sound waves in the cochlea cause deflection ... We previously reported that CIB2 binds to WHRN and is essential for stereocilia staircase architecture of cochlear hair cells. Here, we refine the ... ... stereocilia functional architecture and self-renewal. Rzadzinska AK 1 ,. Schneider ME ,. Davies C ,. Riordan GP ,. Kachar B. Author information. Affiliations. 1 ... ... stereocilia; GZ, Golgi zone; NF, not found; GalTase, galactosyltransferase; α-SMA, alpha smooth muscle actin; Cx43, connexin-43; BP, basal part; VEGF ... This article obtains the stereocilia movement generated by basilar membrane (BM) vibration based on the positional relationship between the various structures ... Mar 28, 2017 ... Mechanotransducer channels at the tips of sensory stereocilia of inner ear hair cells are gated by the tension of 'tip links' ...