How do neurotransmitters affect hair cells and stereocilia?

Jan 25, 2022 ... Bending the stereocilia toward the kinocilium depolarizes the cell and results in increased afferent activity. Bending the stereocilia away from ... Jul 18, 2022 ... Espins are actin-bundling proteins that have a well-characterized role in stereocilia formation; loss of function mutations in Espin result in ... Oct 13, 2017 ... These two models could be tested by manipulating Ca2+ or actin-depolymerizing molecules in the stereocilium and examining effects on stereocilia ... May 24, 2023 ... Stereocilia are miniscule hair-like protrusions on the surface of sensory cells (also called hair cells) found deep within the cochlear and ... PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing. Nature Comm. 10: 3801. 153. György, B., Nist-Lund, C., Pan, B., Asai ... Jun 20, 2019 ... We report that TRIOBP-5 is essential for thickening bundles of F-actin in rootlets, establishing their mature dimensions and for stiffening supporting cells. Apr 13, 2017 ... Because the actin filaments in the stereocilia of hair borders still remain as compact bun- dles, albeit very disordered, there must be an addi-. Mar 21, 2011 ... The mechanotransducer channels of auditory hair cells are gated by tip-links, oblique filaments that interconnect the stereocilia of the ... Mar 13, 2020 ... When stereocilia become damaged, they do not regenerate, and sensorineural hearing loss is the result. While there are no surgeries that can ... The stereocilia are simpler, containing only an actin cytoskeleton. Each stereocilium tapers where it inserts into the apical membrane, forming a hinge ...