Could gene therapy be used to repair damaged stereocilia?

Sep 8, 2022 ... Stereocilia transform audio waves of sound into electrical impulses ... Our cells rely on a healthy supply of blood throughout our body, and this ... They have more stereocilia and long stereocilia relative to kinocilia heights. Tip link tensions show parallel behavior in peripheral columns of the bundle ... stereocilia it connects. It also explains the very similar rotational operating range encountered in VHCs and. OHCs of the neonatal mouse, as their rootlet ... Jan 21, 2021 ... Abstract. Inner ear hair cells detect sound-induced displacements and transduce these stimuli into electrical signals in a hair bundle that ... Apr 21, 2025 ... Cilia are made of microtubules, while stereocilia and microvilli are made of actin filaments. The shortest is microvilli, intermediate height ... Jul 18, 2022 ... Espins are actin-bundling proteins that have a well-characterized role in stereocilia formation; loss of function mutations in Espin result in ... ... stereocilia. These stereocilia are grouped into hair bundles, and the stereocilia in each hair bundle work together to facilitate the conversion of physical ... Nov 3, 2021 ... ... stereocilia. Sound vibrations cause the stereocilia to sway, which leads to the hair cell sending signals to nearby neurons that relay ... Dec 4, 2021 ... The longer stereocilia that project from the outer hair cells actually attach to the tectorial membrane. All of the stereocilia are ... Jun 20, 2019 ... We report that TRIOBP-5 is essential for thickening bundles of F-actin in rootlets, establishing their mature dimensions and for stiffening supporting cells.