Can organoids be used to study stereocilia development and regeneration in vitro?

Abstract. Stereocilia are actin-based protrusions on auditory and vestibular sensory cells that are required for hearing and balance. They convert physical ... Aug 5, 2022 ... Within the inner ear is the cochlea, which is lined with tiny hair cells called stereocilia. The stereocilia's job is to convert incoming ... ... stereocilia; GZ, Golgi zone; NF, not found; GalTase, galactosyltransferase; α-SMA, alpha smooth muscle actin; Cx43, connexin-43; BP, basal part; VEGF ... Oct 13, 2017 ... These two models could be tested by manipulating Ca2+ or actin-depolymerizing molecules in the stereocilium and examining effects on stereocilia ... Mar 11, 2019 ... The tip links are connected to stretch-activated cation channels on the tips of the stereocilia. When a sound wave vibrates the basilar membrane ... Jul 21, 2022 ... Sensorineural Hearing Loss. Inside the inner ear is the cochlea, which is lined with tiny hair cells called stereocilia that convert soundwaves ... May 24, 2023 ... Stereocilia are miniscule hair-like protrusions on the surface of sensory cells (also called hair cells) found deep within the cochlear and ... Aug 11, 2015 ... 2 Answers 2 ... Stereocilia are basically modified microvilli. They are much longer than microvilli, and lack the villin protein. According to ... Jun 11, 2019 ... ... stereocilia. The stereocilia within the same hair bundle have differing lengths. They are aligned in an orderly way to form a wedge shape ... This article obtains the stereocilia movement generated by basilar membrane (BM) vibration based on the positional relationship between the various structures ...