How can high-throughput screening and other drug discovery approaches be used to identify novel therapeutic agents against Pseudomonas aeruginosa?

PA does appear to be an 'egg' rather than a 'chicken' in COPD, with mounting evidence of its role in exacerbations, hospitalizations, and mortality. Jan 20, 2023 ... Pseudomonas aeruginosa is an opportunistic pathogen that requires iron for growth and virulence, yet this nutrient is sequestered by the ... Antibiotics with a novel mode of action will be needed to avoid cross resistance against currently used therapeutic agents. Importantly, antivirulence drugs are ... Apr 11, 2024 ... Key points · Pseudomonas aeruginosa (P. aeruginosa) infections typically occur in healthcare settings. · Good hand hygiene and infection ... Pseudomonas aeruginosa is a bacteria that can be found in hot tubs and pools. Pseudomonas aeruginosa is a bacteria known commonly to cause “hot tub. Dec 5, 2013 ... Conditions Associated with the Cystic Fibrosis Defect Promote Chronic Pseudomonas aeruginosa Infection. Benjamin J. Staudinger. Pseudomonas aeruginosa is the most common strain that causes infections in humans. Around 13% of P. aeruginosa infections are multidrug-resistant (MDR-PA). Mild ... May 23, 2023 ... Carbapenem Resistant Pseudomonas aeruginosa (CRPA) · P. aeruginosa causes an estimated 51,000 health care-associated infections in the U.S. ... P. aeruginosa is a bacterial pathogen that causes a variety of opportunistic infections, including pulmonary infections in cystic fibrosis patients. The mutant ... Pseudomonas aeruginosa infections are the predominant driver of CF lung disease, and airway isolates are frequently resistant to multiple antimicrobials ...